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北京义翘神州科技股份有限公司

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北京义翘神州科技股份有限公司
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公 司 名:北京义翘神州科技股份有限公司

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北京义翘神州科技股份有限公司 ( Sino Biological Inc. )是一家从事生物试剂研发、生产、销售并提供技术服务的生物科技公司,主要业务包括重组蛋白、抗体、基因和培养基等产品,以及重组蛋白、抗体的开发和生物分析检测等服务。
义翘科技为全球的药品研发企业和生命科学研究机构提供高质量的生物试剂产品和高水平的技术服务。公司目前生产和销售的现货产品种类超过4.6万种,其中重组蛋白约6,000种,包括超过3,800种人源细胞表达重组蛋白产品,能够全面满足客户对于最接近人体天然蛋白结构和性质的重组蛋白需求;公司还能提供约12,000种抗体,其中单克隆抗体数量约4,600种,能够覆盖生命科学研究的多个领域,为分子生物学、细胞生物学、免疫学、发育生物学、干细胞研究等基础科研方向和创新药物研发提供“一站式”生物试剂产品和技术服务。客户涵盖大学、科研院所、医药研发企业等国内外各类生物研发单位。公司已经在美国、欧洲等地建立了子公司,在上海建立分公司,已成为生物试剂行业国内领先的科技公司之一。

用于流感病毒抗原检测的抗体对

Antibodies for Influenza Antigen Test

流感病毒核蛋白(NP)在病毒复制和宿主适应中起关键作用,属于结构蛋白。针对NP蛋白的抗体通常用于各种流感病毒的免疫检测中,如ELISA、FLA、荧光抗体检测等。这些检测可用于基础研究和临床诊断。由于不同流感毒株之间抗原漂移或转移的频率很高,因此在流感诊断中特别需要广谱流感抗体。

义翘神州已鉴定出6对广谱抗体,分别针对甲型流感和乙型流感的NP蛋白。通过夹心法ELISA检测,这些抗原-抗体配对具有高灵敏度,可达到皮克级(pg)。

Antibody Pairs for Pan Influenza A NP Detection

Antibody Pairs Capture Ab Detection Ab
PanA-1 40205-MM16 40208-R014
PanA-2 40205-R063 40205-MM18
PanA-3 40208-R117 40205-MM18
 

Antibody Pairs for Pan Influenza B NP Detection

Antibody Pairs Capture Ab Detection Ab
PanB-1 40438-R004 40438-MM10
PanB-2 40438-R036 40438-MM10
PanB-3 40438-MM05 40438-R036

High Sensitivity (pg level)

Broad Spectrum and High Specificity

These antibody pairs can detect a broad spectrum of strains within the target subtype, without any cross-reactivity with the other subtypes.
24 kinds of influenza antigens from A or B have been tested by ELISA assay

Broad Spectrum and High Specificity

The Aforementioned Antigens:

B-1:  40783-V08B (B, B/Brisbane/60/2008) A-8:  40774-V08B (H1N1, A/Victoria/2570/2019 | A/Wisconsin/588/2019)
B-2:  40782-V08B (B, B/Colorado/06/2017) A-9:  40033-V08B (H2N2, A/Ann Arbor/6/1960)
B-3:  40438-V08B (B, B/Florida/4/2006) A-10:  40207-V08B (H3N2, A/Aichi/2/1968)
B-4:  40500-V08B (B, B/Phuket/3073/2013) A-11:  40778-V08B (H3N2, A/Cambodia/e0826360/2020 (H3N2)-like)
B-5:  40755-V08B (B, B/Washington/02/2019) A-12:  40208-V08B (H3N2, A/Hong Kong/1/1968)
A-1:  40204-V08B (H1N1, A/Brevig Mission/1/1918) A-13:  40753-V08B (H3N2, A/Hong Kong/2671/2019)
A-2:  40776-V08B (H1N1, A/Brisbane/02/2018) A-14:  40754-V08B (H3N2, A/Hong Kong/45/2019)
A-3:  40205-V08B (H1N1, A/California/07/2009) A-15:  40781-V08B (H3N2, A/Hong Kong/4801/2014 )
A-4:  40723-V08B (H1N1, A/Guangdong-Maonan/SWL1536/2019) A-16:  40779-V08B (H3N2, A/Kansas/14/2017)
A-5:  40724-V08B (H1N1, A/Hawaii/70/2019) A-17:  40499-V08B (H3N2, A/Switzerland/9715293/2013)
A-6:  40777-V08B (H1N1, A/Michigan/45/2015) A-18:  40110-V08B (H7N9, A/Anhui/1-BALF_RG6/2013)
A-7:  11675-V08B (H1N1, A/Puerto Rico/8/34/Mount Sinai) A-19:  40111-V08B (H7N9, A/Shanghai/2/2013)

High Binding Affinity

The binding affinity between immobilized Influenza B NP protein (Cat#: 40500-V08B) with the anti-NP antibody (Cat#: 40438-R036) in BLI assay.

 

The binding affinity between immobilized Influenza A NP protein (Cat#: 40774-V08B) with the anti-NP antibody (Cat#: 40205-R063) in BLI assay.

Antibody Cocktail Can Successfully Detect both A and B Type Flu

The combination of A and B antibody pairs can allow detection of both subtypes.

 

High Production Quality

Our products and processes are ISO13485 certified. The purity of these antibodies is >95% as assessed by SEC-HPLC.

Other Pan Influenza NP Antibodies

16 Pan Influenza A or B Nucleoprotein antibodies have been developed and validated by ELISA and WB assays.

Pan Influenza A NP Antibodies

40208-MM03   40208-R014   40208-MM04   40208-R010   40208-R061
 
40208-R113   40208-R117   40205-MM16   40205-MM18   40205-R063

Pan Influenza B NP Antibodies

40438-MM05   40438-R016   40438-MM09   40438-R036   40438-R004   40438-MM10

Western Blot Analysis of Nucleoprotein Antibodies to 24 Influenza Antigens

Lane 1: 40204-V08B | H1N1 (A/Brevig Mission/1/1918)
Lane 2: 40776-V08B | H1N1 (A/Brisbane/02/2018)*
Lane 3: 40205-V08B | H1N1 (A/California/07/2009)
Lane 4: 40723-V08B | H1N1 (A/Guangdong-Maonan/SWL1536/2019)*
Lane 5: 40724-V08B | H1N1 (A/Hawaii/70/2019)*
Lane 6: 40777-V08B | H1N1 (A/Michigan/45/2015)*
Lane 7: 11675-V08B | H1N1 (A/Puerto Rico/8/34/Mount Sinai)
Lane 8: 40774-V08B | H1N1 (A/Victoria/2570/2019A/Wisconsin/588/2019)
Lane 9: 40033-V08B | H2N2 (A/Ann Arbor/6/1960)
Lane 10: 40207-V08B | H3N2 (A/Aichi/2/1968)
Lane 11: 40778-V08B | H3N2 (A/Cambodia/e0826360/2020 (H3N2)-like)
Lane 12: 40208-V08B | H3N2 (A/Hong Kong/1/1968)
Lane 13: 40753-V08B | H3N2 (A/Hong Kong/2671/2019)*
Lane 14: 40754-V08B | H3N2 (A/Hong Kong/45/2019)*
Lane 15: 40781-V08B | H3N2 (A/Hong Kong/4801/2014)*
Lane 16: 40779-V08B | H3N2 (A/Kansas/14/2017)*
Lane 17: 40499-V08B | H3N2 (A/Switzerland/9715293/2013)*
Lane 18: 40110-V08B | H7N9 (A/Anhui/1-BALF_RG6/2013)
Lane 19: 40111-V08B | H7N9 (A/Shanghai/2/2013)
Lane 20: 40783-V08B | Influenza B (B/Brisbane/60/2008)*
Lane 21: 40782-V08B | Influenza B (B/Colorado/06/2017)*
Lane 22: 40438-V08B | Influenza B (B/Florida/4/2006)
Lane 23: 40500-V08B | Influenza B (B/Phuket/3073/2013)*
Lane 24: 40755-V08B | Influenza B (B/Washington/02/2019)*

*: Antigen from 2015-2022 Influenza Vaccine Strain

Pan Influenza A and B Hemagglutinin Antibody

Because of the distinct role of HA, it is widely used for research on antibodies against influenza. WB and ELISA assay have been performed to confirm the recognition of HA antigens. Results show that rabbit Mab 86001-RM01 and 11053-R004 are broad spectrum antibodies for Influenza A and B, respectively.

Western Blot Analysis of Hemagglutinin Antibodies to 20 Influenza Antigens


Anti-Influenza A HA rabbit mAb (Cat#: 86001-RM01) at 1:5000 dilution.
 
Anti-Influenza B HA rabbit mAb (Cat#: 11053-R004) at 1:10000 dilution.

Lane 1: 40719-V08H | H1N1 (A/Brisbane/02/2018) *
Lane 2: 11055-V08H | H1N1 (A/California/04/2009)
Lane 3: 11085-V08B | H1N1 (A/California/07/2009)*
Lane 4: 40717-V08H | H1N1 (A/Guangdong-Maonan/SWL1536/2019)*
Lane 5: 40567-V08H1 | H1N1 (A/Michigan/45/2015)*
Lane 6: 11684-V08H | H1N1 (A/Puerto Rico/8/1934)
Lane 7: 40787-V08H | H1N1 (A/Wisconsin/588/2019) / (A/Victoria/2570/2019) *
Lane 8: 11056-V08H | H3N2 (A/Brisbane/10/2007)
Lane 9: 40789-V08H | H3N2 (A/Cambodia/e0826360/2020)*
Lane 10: 40721-V08H | H3N2 (A/Hong Kong/2671/2019)*
Lane 11: 40765-V08H | H3N2 (A/Hong Kong/45/2019)*
Lane 12: 40555-V08B | H3N2 (A/Hong Kong/4801/2014)*
Lane 13: 40720-V08H | H3N2 (A/Kansas/14/2017) *
Lane 14: 40580-V08H | H3N2 (A/Singapore/INFIMH-16-0019/2016)*
Lane 15: 40497-V08B | H3N2 (A/Switzerland/9715293/2013)*
Lane 16: 40016-V08B | Influenza B (B/Brisbane/60/2008)*
Lane 17: 40581-V08H | Influenza B (B/Colorado/06/2017)*
Lane 18: 11053-V08H | Influenza B (B/Florida/4/2006)
Lane 19: 40498-V08B | Influenza B (B/PHUKET/3073/2013)*
Lane 20: 40722-V08H Influenza B (B/Washington/02/2019)*

*: Antigen from 2015-2022Influenza Vaccine Strain